Hackett’s project is carefully presented in “The GLP-1 Lifestyle: Transform Your Metabolism & Achieve Lasting Weight Loss With Or Without Semaglutide” ($14.99 in paperback, independently published, see facebook.com/groups/glp1lifestyle; also for Amazon Kindle). His book is for educational purposes and is “not a substitute for professional medical advice.”
“Semaglutide,” he writes, “is a medication initially designed to treat type 2 diabetes”; it’s also proving effective in “harnessing the power of our own biology, targeting the hormonal imbalances and physiological mechanisms that contribute to weight gain. At least that’s what the commercials want you to believe. Of course, part is true, part is false, and part is unknown.” (A lengthy bibliography points to medical journal articles as well as non-academic sources.)
Semaglutides are GLP-1 “receptor agonists” (binding to a cell receptor producing a similar effect as the body’s natural function) which are in such medications as Ozempic, Wegovy and Rybelsus. “GLP-1 influences digestion by slowing down the rate at which food leaves the stomach,” stimulates “insulin release from the pancreas,” and sends “a message to the brain that we’ve had enough to eat.”
There’s great detail about how GLP-1 works but Hackett alerts readers to side effects (some severe)--and the rebound, when weight comes right back. Instead, “the goal is to utilize semaglutide as a catalyst for change, a springboard to a healthier lifestyle that can be sustained even after the medication is discontinued.”
The second half of the book details a holistic approach to weight control, focusing on exercise and meal plans that aid one’s gut health; the gut “produces GLP-1” and “is the epicenter of the entire immune system.” Hackett also encourages sunlight exposure (for vitamin D production) and “grounding,” putting bare feet on the earth, which aids in stress reduction. And, if needed, supplements.
Hackett refrains from exaggerated claims, even for measures he advocates. His focus at the end is on healthy habits and not wonder drugs, however wonderful they may be.